cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation
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چکیده
منابع مشابه
cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation.
p66Shc-dependent ROS production contributes to many pathologies including ischemia/reperfusion injury (IRI) during solid organ transplantation. Inhibiting p66Shc activation may provide a novel therapeutic approach to prevent damage, which is poorly managed by antioxidants in vivo. Previous work suggested that pro-oxidant and a pro-apoptotic function of p66Shc required mitochondrial import, whic...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep20930